Cobalt(II)‐Catalyzed Asymmetric Olefin Cyclopropanation with α‐Ketodiazoacetates

Abstract

Porphyrin and Co.: The cobalt(II) complex 1 is an effective metalloradical catalyst for cyclopropanation of alkenes with α-acetodiazoacetates at room temperature to yield E-1,1-cyclopropaneketoesters in high yields with both high diastereo- and enantioselectivities. Epimerization of the resulting enantioenriched E diastereoisomers into the corresponding Z isomers with retention of the enantiopurity is promoted by iodide. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.