Concepedia

Loss of heterozygosity on chromosome 10q in glioblastomas, and its association with other genetic alterations and survival in Indian patients

Vaishali Suri, Aanchal Kakkar, Prerana Jha, Arti Srivastava, Vikas Sharma, Pankaj Pathak, MeharChand Sharma, ManishSingh Sharma, ShashankS Kale, Kunzang Chosdol,

Neurology India · 2011 · 22 citations · 31 references

DOI

Abstract

LOH 10q is a frequent genetic abnormality in GBM in Indian patients, is seen more frequently in older adults, and its presence is associated with shorter survival. The single best marker to determine LOH 10q status is D10S1765 at the PTEN region.

References

31

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

Peter A. Steck, Mark A. Pershouse, Samar A. Jasser et al. · Nature Genetics · 1997 · 2.8K citations

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Impact of mutant p53 functional properties on<i>TP53</i>mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

Audrey Petitjean, Ewy A. Mathé, Shunsuke Kato et al. · Human Mutation · 2007 · 1.6K citations · Full text

, , +20

Molecular Determinants of the Response of Glioblastomas to EGFR Kinase Inhibitors

Ingo K. Mellinghoff, Maria Y. Wang, Igor Vivanco et al. · New England Journal of Medicine · 2005 · 1.4K citations · Full text

Genetic Pathways to Glioblastoma

Hiroko Ohgaki, Pierre Dessen, Benjamin Jourde et al. · Cancer Research · 2004 · 1.3K citations · Full text