A Null Allele Impairs Function of CYP2C76 Gene in Cynomolgus Monkeys: A Possible Genetic Tool for Generation of a Better Animal Model in Drug Metabolism

Evolutionary and Biomedical Insights from the Rhesus Macaque Genome

Richard A. Gibbs, Jeffrey Rogers, Michael G. Katze et al. · Science · 2007 · 1.4K citations · Full text

Life Sciences, Evolutionary Biology, Genetics +17

Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences.

Osamu Gotoh · Journal of Biological Chemistry · 1992 · 1.2K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development

Karen Niederreither, Suzan Abu–Abed, Brigitte Schuhbaur et al. · Nature Genetics · 2002 · 233 citations

Life Sciences, Developmental Biology, Genetics +12

Comparisons of phase I and phase II in vitro hepatic enzyme activities of human, dog, rhesus monkey, and cynomolgus monkey.

J E Sharer, Lisa A. Shipley, Mark VandenBranden et al. · Drug Metabolism and Disposition · 1995 · 168 citations

Medicine, Biochemistry, Pharmacology +17

CYP2C76, a Novel Cytochrome P450 in Cynomolgus Monkey, Is a Major CYP2C in Liver, Metabolizing Tolbutamide and Testosterone

Yasuhiro Uno, Hideki Fujino, Go Kito et al. · Molecular Pharmacology · 2006 · 119 citations

Medicine, Biochemistry, Molecular Biology +12