The high frequency of complement factor H related <i>CFHR1</i> gene deletion is restricted to specific subgroups of patients with atypical haemolytic uraemic syndrome

Abstract

The high frequency of CFHR1 deletion in aHUS patients is restricted to the subgroups of patients presenting with anti-FH autoantibodies or, to a lesser degree, CFI mutation. These results suggest that the CFHR1 deletion plays a secondary role in susceptibility to aHUS.