<i>Helicobacter pylori</i> Infection and Family History of Gastric Cancer Decrease Expression of <i>FHIT</i> Tumor Suppressor Gene in Gastric Mucosa of Dyspeptic Patients

Abstract

The decreased FHIT gene expression associated with hereditary factors and with H. pylori infection, especially with vacA(+)cagA(+)-positive strains, may be related to gastric carcinoma development.