Concepedia

Natural products active against African trypanosomes: a step towards new drugs

Sara Hoet, Fred R. Opperdoes, Joëlle Quetin‐Leclercq

Natural Product Reports · 2004 · 156 citations · 54 references

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Concepts

Abstract

This review covers compounds with activity on African trypanosomes (mainly Trypanosoma brucei subsp.,T congolense and T vivax) isolated from natural sources and is organized according to the structure of the etabolites (alkaloids, phenolic derivatives, quinones, terpenes and other metabolites). The literature from he mid-1980s up to June 2003 is reviewed and 89 references are cited.

References

54

2- and 3-Substituted 1,4-Naphthoquinone Derivatives as Subversive Substrates of Trypanothione Reductase and Lipoamide Dehydrogenase from <i>Trypanosoma</i> <i>c</i><i>ruzi</i>:  Synthesis and Correlation between Redox Cycling Activities and in Vitro Cytotoxicity

Laurence Salmon-Chemin, Eric Buisine, Vanessa Yardley et al. · Journal of Medicinal Chemistry · 2001 · 257 citations · Full text

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Potentiation of the antimalarial activity of qinghaosu by methoxylated flavones

Barry C. Elford, Margaret Roberts, J. Phillipson et al. · Transactions of the Royal Society of Tropical Medicine and Hygiene · 1987 · 158 citations

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Synthesis, Cytotoxicity, and Antiplasmodial and Antitrypanosomal Activity of New Neocryptolepine Derivatives

Tim H. M. Jonckers, Sabine Van Miert, K. Cimanga et al. · Journal of Medicinal Chemistry · 2002 · 151 citations

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The fall and rise of sleeping sickness

Michael P. Barrett · The Lancet · 1999 · 138 citations

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Ajoene Is an Inhibitor and Subversive Substrate of Human Glutathione Reductase and <i>Trypanosoma </i><i>cruzi</i> Trypanothione Reductase:  Crystallographic, Kinetic, and Spectroscopic Studies

Helge Gallwitz, Susanne Bonse, Luis Alfonso Martínez‐Cruz et al. · Journal of Medicinal Chemistry · 1999 · 124 citations

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