Total Synthesis of Tubulysin U and V

Abstract

Multicomponent method: Tubulysins are among the most potent cytotoxic agents known. Now the first total synthesis of some members has been achieved by utilizing a rapid three-component reaction for the synthesis of the unusual central thiazole amino acid tubuvaline (see scheme; Boc=tert-butoxycarbonyl, Ac=acetyl), thereby opening new perspectives for anticancer drug development. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z601259_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.