Publication | Open Access

Discovery of novel isothiazole inhibitors of the TrkA kinase: Structure–activity relationship, computer modeling, optimization, and identification of highly potent antagonists

Medicinal ChemistryDrug TargetNovel Isothiazole InhibitorsBiochemistryMedicineNatural SciencesRational Drug DesignTrka KinaseDrug DevelopmentPotent AntagonistsPharmacologyMolecular ModelingDrug Discovery