Journal of Clinical Oncology · 2011 · 198 citations · 24 references
A proportion of men experience an upgrade in Gleason score while undergoing active surveillance. Men who experience early upgrading likely represent initial sampling error, whereas later upgrading may reflect tumor dedifferentiation.
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Active surveillance for the management of prostate cancer in a contemporary cohort
Marc Dall’Era, Badrinath R. Konety, Janet E. Cowan et al. · Cancer · 2008 · 400 citations · Full text
Gleason Score and Lethal Prostate Cancer: Does 3 + 4 = 4 + 3?
Jennifer R. Rider, Sven Perner, Meir J. Stampfer et al. · Journal of Clinical Oncology · 2009 · 391 citations · Full text