Concepedia

Delayed Preconditioning-Mimetic Action of Nitroglycerin in Patients Undergoing Coronary Angioplasty

Massoud A. Leesar, Marcus F. Stoddard, Buddhadeb Dawn, Venu Jasti, Ronald R. Masden, Roberto Bolli

Circulation · 2001 · 163 citations · 23 references

DOIFull text

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Abstract

NTG protects human myocardium against ischemia 24 hours after its administration. To the best of our knowledge, this is the first report that a late PC effect can be recruited pharmacologically in humans. The results suggest that prophylactic administration of nitrates could be a novel approach to the protection of the ischemic myocardium in patients.

References

23

ISIS-4: A randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58 050 patients with suspected acute myocardial infarction

The Lancet · 1995 · 1.8K citations

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GISSI-3: effects of lisiriopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction

GRUPPOITALIANOPERLOSTUDIODELL · The Lancet · 1994 · 1.1K citations

, , +9

ISIS-4 - A randomised factorial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58.050 patient with suspected acute myocardial-infarction.

Robert T. Collins, R Peto, Marcus Flather et al. · Ghent University Academic Bibliography (Ghent University) · 1995 · 1.1K citations

, , +8

Adaptation to ischemia during percutaneous transluminal coronary angioplasty. Clinical, hemodynamic, and metabolic features.

Ezra Deutsch, Mark Berger, William G. Kussmaul et al. · Circulation · 1990 · 595 citations

, , +18

Adenosine receptor involvement in a delayed phase of myocardial protection 24 hours after ischemic preconditioning.

Gary F. Baxter, Michael Marber, Vanlata C. Patel et al. · Circulation · 1994 · 271 citations · Full text

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