Concepedia

Claudin-1 protein is a major factor involved in the tumorigenesis of colorectal cancer.

Qun Huo, Tetsushi Kinugasa, Lin Wang, Jian Huang, Jun Zhao, Hirotomo Shibaguchi, Motomu Kuroki, Toshihiro Tanaka, Yuichi Yamashita, Kazuki Nabeshima,

PubMed · 2009 · 73 citations · 30 references

Abstract

CL-1 plays a pivotal role in cell morphology and behavior in the colonic epithelium. CL-1 protein may therefore be one of the major factors involved in the tumorigenesis of CRC.

References

30

Occludin: a novel integral membrane protein localizing at tight junctions.

Mikio Furuse, Tetsuaki Hirase, Masahiko Itoh et al. · The Journal of Cell Biology · 1993 · 2.5K citations · Full text

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Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

Mikio Furuse, Kohji Fujita, Takashi Hiiragi et al. · The Journal of Cell Biology · 1998 · 2.1K citations · Full text

Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins

Masahiko Itoh, Mikio Furuse, Kazumasa Morita et al. · The Journal of Cell Biology · 1999 · 1.1K citations · Full text

General rules for clinical and pathological studies on cancer of the colon, rectum and anus

Dennosuke Jinnai · Surgery Today · 1983 · 634 citations

, , +11

Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer

Punita Dhawan · Journal of Clinical Investigation · 2005 · 539 citations · Full text

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