The Folding and Unfolding Kinetics of the i‐Motif Structure Formed by the C‐Rich Strand of Human Telomere DNA

Abstract

Return to the fold. Nucleic acids with four tandem cytidine-rich repeats can fold into a structure called the i-motif at acidic pH. The folding- and unfolding-rate constants of such a sequence in vertebrate telomere DNA were measured. Protons were found to promote i-motif formation by increasing the folding and decreasing the unfolding. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2268/2005/z500175_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.