Catalytic Asymmetric Allenylation of Malonates with the Generation of Central Chirality

Abstract

Water plays an important role in a palladium-catalyzed allenylation of diethyl malonate with 2,3-allenyl acetates to yield centrally chiral allenyl malonates bearing synthetically useful functional groups (see scheme). The products were formed with 92–96 % ee in the presence of a bulky, electron-rich biphenyl ligand at room temperature. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.