Bioinformatics · 2000 · 545 citations · 9 references
Life SciencesBiostatisticsGeneticsGenomic Data AnalysisPopulation GeneticsStatistical GeneticsGene MappingGenetic LinkageLinkage AnalysisLinkage DisequilibriumEquilibriumGenetic Linkage DisequilibriumLinkage Disequilibrium AnalysisLinkage Disequilibrium EstimationLinkage Disequilibrium MappingLinkage Disequilibrium ModelingMultilocus Linkage DisequilibriumNull Hypothesis
Abstract Summary: LIAN is a program to test the null hypothesis of linkage equilibrium for multilocus data. LIAN incorporates both a Monte Carlo method as well as a novel algebraic method to carry out the hypothesis test. The program further returns the genetic diversity of the sample and the pairwise distances between its members. Availability: LIAN can be accessed at http://soft.ice.mpg.de/lian Contact: haubold@ice.mpg.de To whom correspondence should be addressed.
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John Maynard Smith, N. H. Smith, Mark Allen O’Rourke et al. · Proceedings of the National Academy of Sciences · 1993 · 1.8K citations