The G6055A (G2019S) mutation in <i>LRRK2</i> is frequent in both early and late onset Parkinson’s disease and originates from a common ancestor

Abstract

G2019S is the most common genetic determinant of Parkinson's disease identified so far. It is especially frequent among cases with familial Parkinson's disease of both early and late onset, but less common among sporadic cases. These findings have important implications for diagnosis and genetic counselling in Parkinson's disease.