Bedaquiline Metabolism: Enzymes and Novel Metabolites

The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis

Andreas H. Diacon, Alexander S. Pym, Martin P. Grobusch et al. · New England Journal of Medicine · 2009 · 839 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +14

CYP3A4 Induction by Drugs: Correlation between a Pregnane X Receptor Reporter Gene Assay and CYP3A4 Expression in Human Hepatocytes

Gang Luo, Mark R. Cunningham, Sean Kim et al. · Drug Metabolism and Disposition · 2002 · 447 citations

Medicine, Pharmacology, Biochemical Pharmacology +15

Randomized Pilot Trial of Eight Weeks of Bedaquiline (TMC207) Treatment for Multidrug-Resistant Tuberculosis: Long-Term Outcome, Tolerability, and Effect on Emergence of Drug Resistance

Andreas H. Diacon, Peter R. Donald, Alexander S. Pym et al. · Antimicrobial Agents and Chemotherapy · 2012 · 380 citations · Full text

Pharmacy, Pharmacology, Pharmacotherapy +13

Induction of CYP2C genes in human hepatocytes in primary culture.

Sabine Gerbal‐Chaloin, Jean‐Marc Pascussi, Lydiane Pichard‐Garcia et al. · PubMed · 2001 · 318 citations

Medicine, Biochemistry, Pharmacology +15

Use of the bromine isotope ratio in HPLC-ICP-MS and HPLC-ESI-MS analysis of a new drug in development

Filip Cuyckens, Lieve Balcaen, Kenny De Wolf et al. · Analytical and Bioanalytical Chemistry · 2008 · 67 citations

Pharmacy, Chemistry, Pharmaceutical Analysis +16