Unresponsive wakefulness syndrome: a new name for the vegetative state or apallic syndrome

TLDR

Patients who open their eyes after coma yet show no response to commands are traditionally called vegetative state, a term that carries pejorative connotations and has led to diagnostic uncertainty. The authors propose renaming the condition as unresponsive wakefulness syndrome (UWS) to eliminate the pejorative image of vegetative state and reduce diagnostic errors. UWS is defined by the presence of wakefulness (eye opening) without response to commands, describing a neutral clinical syndrome. The study offers clinicians the option to adopt the term unresponsive wakefulness syndrome (UWS) for this patient population.

Abstract

Some patients awaken from coma (that is, open the eyes) but remain unresponsive (that is, only showing reflex movements without response to command). This syndrome has been coined vegetative state. We here present a new name for this challenging neurological condition: unresponsive wakefulness syndrome (abbreviated UWS).Many clinicians feel uncomfortable when referring to patients as vegetative. Indeed, to most of the lay public and media vegetative state has a pejorative connotation and seems inappropriately to refer to these patients as being vegetable-like. Some political and religious groups have hence felt the need to emphasize these vulnerable patients' rights as human beings. Moreover, since its first description over 35 years ago, an increasing number of functional neuroimaging and cognitive evoked potential studies have shown that physicians should be cautious to make strong claims about awareness in some patients without behavioral responses to command. Given these concerns regarding the negative associations intrinsic to the term vegetative state as well as the diagnostic errors and their potential effect on the treatment and care for these patients (who sometimes never recover behavioral signs of consciousness but often recover to what was recently coined a minimally conscious state) we here propose to replace the name.Since after 35 years the medical community has been unsuccessful in changing the pejorative image associated with the words vegetative state, we think it would be better to change the term itself. We here offer physicians the possibility to refer to this condition as unresponsive wakefulness syndrome or UWS. As this neutral descriptive term indicates, it refers to patients showing a number of clinical signs (hence syndrome) of unresponsiveness (that is, without response to commands) in the presence of wakefulness (that is, eye opening).