Concepedia

Peptides. Part XXVI. Analogues of gastrin containing leucine in place of methionine

G. W. Kenner, J. J. Mendive, R. C. Sheppard

Journal of the Chemical Society C Organic · 1968 · 13 citations · 0 references

Concepts

Life SciencesBiochemistryHormone BiochemistryOrganic ChemistryAmino Acid ChemistryHormone StructurePeptide ChemistryPeptide Hormone BiochemistryBiological Activity FeaturesDigestive Tract PeptidesPeptide Hormone StructureSynthetic Peptide Analogs

Abstract

Syntheses of two heptadecapeptide analogues of the hormone gastrin, viz. [Leu15] and [Leu5,Leu15]-porcine gastrin I are described. Both compounds exhibit the full biological activity of the natural hormone.