Antimicrobial Agents and Chemotherapy · 1996 · 57 citations · 30 references
Life SciencesMicrobiologyMolecular BiologyAntimicrobial ResistanceMedical MicrobiologyMicrobial GeneticsAntibacterial ResistanceAntibiotic ResistanceAntibiotic Resistance GeneticsAntibiotic Resistance MechanismsEnzyme InhibitionMechanisms Of Antimicrobial ResistanceBinding Mode AnalysisFluoroquinolone Resistance MechanismsMethicillin ResistanceResistance Mechanisms In Gram-negative BacteriaResistance Mechanisms In Gram-positive BacteriaResistance Mechanisms In StaphylococciResistance Mechanisms In Streptococci
The sequence of the gyrase B subunit gene from Staphylococcus aureus strains resistant to the gyrase B subunit inhibitors cyclothialidine, coumermycin, and novobiocin has been determined. The residues altered in the resistant gyrase B subunits map to the ATP-binding region, suggesting that the drugs inhibit ATP binding and hydrolysis. The pattern of cross-resistances indicates that the detailed binding mode of the compounds differs.
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Crystal structure of an N-terminal fragment of the DNA gyrase B protein
Dale B. Wigley, G.J. Davies, E.J. Dodson et al. · Nature · 1991 · 524 citations