HIV Type 1 RNA Level as a Clinical Indicator of Renal Pathology in HIV‐Infected Patients

Michelle M. Estrella, Derek M. Fine, Joel E. Gallant, M. Hafizur Rahman, Nagapradeep Nagajothi, Lorraine C. Racusen, Paul J. Scheel, Mohamed G. Atta

Clinical Infectious Diseases · 2006 · 75 citations · 19 references

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Abstract

To determine the value of human immunodeficiency virus type 1 (HIV-1) RNA level in distinguishing HIV-associated nephropathy from non-HIV-associated nephropathy renal pathological conditions, we retrospectively compared renal histopathological findings for 86 HIV-infected patients according to HIV-1 RNA levels. We found that HIV-associated nephropathy was unlikely among patients with HIV-1 RNA levels <400 copies/mL. Hypertensive vascular disease surpassed HIV-associated nephropathy as the most common renal pathological finding among the entire cohort. HIV-1 RNA level did not correlate with renal survival.

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