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The Regulation of DNA Replication and Cell Division in E. coli B/r
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References
1968
Year
Chromosome DynamicsCell DivisionNatural SciencesBacteriologyE. Coli B/rMolecular BiologyDna ReplicationDna SynthesisMechanism (Biology)Cell CycleMicrobiologyMolecular MicrobiologyMedicineMolecular MechanismsProtein BiosynthesisMutagenesisMicrobial Genetics
It has occurred to many that the biological cell must have a mechanism to coordinate DNA replication with cell division (Lark, 1966; Kuempel and Pardee, 1963; Jacob et al., 1963). Evidence supporting a biochemical mechanism is scanty, but recently Walker and Pardee (1968) examined lon− mutants of E. coli and found that cell division was linked to DNA metabolism. Maruyama and Lark (1961) noted that blocking DNA synthesis inhibited cell division, while blocking cell division did not necessarily stop DNA synthesis, implying that cell division is dependent upon DNA replication. Inhibitory agents which are specific for DNA synthesis promote filament formation among bacteria (Cohen and Barner, 1954; Adler and Hardigree, 1965; Howard-Flanders et al., 1964), indicating a functional relationship between DNA synthesis and cell division.