Dihydroxylation of 2-vinylaziridine: efficient synthesis of<scp>d</scp>-ribo-phytosphingosine

Abstract

An efficient and highly stereoselective synthesis of D-ribo-(2S,3S,4R)-phytosphingosine was accomplished in 62% overall yield starting from commercially available (2S)-hydroxymethylaziridine via osmium-catalyzed asymmetric dihydroxylation as a key step.