The Use of Mesoporous Silica in Liquid Chromatography

Abstract

Preparative chromatography is a potential application for mesoporous silica due to its high surface area. Mesoporous spheres (MSs) have been prepared quickly from acid solution (see Figure), and their properties with regard to liquid chromatography and high-performance liquid chromatography (HPLC) explored. A new chromatographic technique, reverse-phase flash HPLC, is presented that relies on the use of these acid-prepared MSs.