Clinical Infectious Diseases · 2003 · 50 citations · 14 references
MedicineInfectious DiseasesNeurologyImmunopathologyNeuroimmunologyVirologyAntiretroviral TherapyCentral Nervous System InfectionsEncephalitisImmunodeficiency DisordersNeuropathology Of InfectionViral InfectionsB Cell AplasiaEarly Antiretroviral TherapyHighly Active Antiretroviral TherapyHiv Antiretroviral TherapyHiv-associated NeuropathologyInfectious EncephalitisNeurological Viral InfectionsViral Encephalitis
Illness occurring during the initial months of highly active antiretroviral therapy (HAART) for human immunodeficiency virus infection may be a consequence of the restoration of an immune response against opportunistic pathogens (i.e., immune restoration disease [IRD]). We describe a young man who had AIDS complicated by parvovirus B19 infection and RBC aplasia and who developed a painless, progressive dyspraxia of the left arm and an expressive dysphasia 4 weeks after commencing effective HAART. Neuroimaging demonstrated multiple right fronto-parietal lesions, and, following extensive investigations, including a brain biopsy, it was concluded that the brain lesions represented IRD associated with parvovirus B19 infection.
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