Genomic ATG16L1 risk allele-restricted Paneth cell ER stress in quiescent Crohn's disease

Abstract

The ATG16L1 T300A polymorphism defines a specific subtype of patients with CD, characterised by Paneth cell ER stress even during quiescent disease. Paneth cell ER stress correlates with bacterial persistence, and is thus likely to modulate antimicrobial functionality of this cell type in patients with CD.