Metabolic, inflammatory and haemostatic effects of a low‐dose continuous combined HRT in women with type 2 diabetes: potentially safer with respect to vascular risk?

Abstract

HRT containing 1 mg oestradiol and 0.5 mg norethisterone may avoid the adverse metabolic effects potentially implicated in the elevated CHD and stroke risk induced by conventional higher dose HRT. This type of preparation may therefore be more suitable than conventional HRT for women at elevated CHD risk such as those with type 2 diabetes. Large randomized controlled trials of such low dose preparations, powered for cardiovascular end points, are now needed.