Carrier status for steroid 21‐hydroxylase deficiency is only one factor in the variable phenotype of acne

Abstract

Although alterations of the CYP21 gene were more common in acne than in controls there is a poor correlation between these events and raised steroids and acne. Factors other than mild impairment of CYP21 contribute to the variability of the clinical phenotype in hyperandrogenic states including acne.