Proceedings of the National Academy of Sciences · 1974 · 317 citations · 19 references
MedicineNeurosciencePharmacologyCellular NeuroscienceNeuro-oncologyNeuropharmacologyDrug ReceptorsNeurotransmitter ReceptorsOpioid AnalgesicsHybridoma Cell LinesNeuroblastoma BiologyOpioid Receptor BindingReceptors
A neuroblastoma x glioma hybrid cell line with well-developed neural properties was found that has high-affinity morphine receptors. The average cell contains approximately 3 x 10(6) receptors. In contrast, parent cells and other neuroblastoma or hybrid cell lines tested had few or no morphine receptors.
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Opiate Receptor: Demonstration in Nervous Tissue
Candace B. Pert, Solomon H. Snyder · Science · 1973 · 2.4K citations
Medicine, Neuroscience, Pharmacology +10