Cyclooxygenase-2 expression and recurrence of colorectal adenomas: effect of aspirin chemoprevention

Abstract

Over-expression of COX-2 was frequent and predominated in large and high-grade dysplasia adenomas. Deep stromal but not epithelial initial expression of COX-2 predicted recurrence of adenomas. Aspirin did not act preferentially on patients whose initial adenomas strongly expressed COX-2.