Thrombosis in Patients with the Lupus Anticoagulant

TLDR

The study retrospectively assessed the frequency of thrombosis in patients with lupus anticoagulant. The authors reviewed 35 patients who met laboratory criteria for lupus anticoagulant to evaluate thrombotic events. Eight of the 35 patients had clinically significant thrombosis, many with concurrent autoimmune disease or phenothiazine use, moderate thrombocytopenia in four, no abnormal bleeding, suggesting an increased thrombotic risk in lupus anticoagulant patients.

Abstract

A retrospective study was carried out to determine the frequency of thrombosis in patients with the lupus anticoagulant. Thirty-five patients fulfilled laboratory criteria for the diagnosis of the lupus anticoagulant. Eight of these patients had evidence of clinically significant thrombosis while their plasma showed a prolonged partial thromboplastin time due to the anticoagulant. Four of the patients with thrombosis had concurrent autoimmune disease and three other patients were receiving phenothiazine medication. Moderate thrombocytopenia was noted in four patients with thrombosis. None of the patients with the lupus anticoagulant bled abnormally. This study suggests that patients with the lupus anticoagulant may be at increased risk of thrombosis.