Distribution of Steroid Sulfatase in Human Tissues

Abstract

Distribution of steroid sulfatase in human tissues was determined by incubating whole homogenates of placenta, hydatidiform mole, fetal membranes, ovarian cortex, corpus luteum, arrhenoblastoma, myometrium, leiomyomata, endometrium, liver, kidney, striated muscle, adipose tissue and skin with 4-14C-dehydroisoandrosterone sulfate. Reproductive tissues and liver had appreciable activity; placenta was by far the most active tissue studied. Placentas of anencephalic fetuses were more active than those of normal infants.