Enantioselective Formation of All‐Carbon Quaternary Stereocenters from Indoles and Tertiary Alcohols Bearing A Directing Group

Abstract

Described is an efficient catalytic asymmetric intermolecular C-C bond-formation process to generate acyclic all-carbon quaternary stereocenters. The reactions overcome the unfavorable steric hindrance around reactive centers, and the competitive elimination (E1), to form a range of useful indole products with excellent efficiency and enantioselectivity.