Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) as Donor Ligands in Organotin(IV) Derivatives: Synthesis, Spectroscopic Characterization and Biological Applications

Abstract

Some new di- and tri-organotin(IV) derivatives of 4 different non-steroidal anti-inflammatory drugs (NSAIDs) with the general formulae R2SnL2 and R3SnL (where R = n-C8H17 and C6H5CH2) and L = 2-[(2,3-dimethylphenyl)amino]benzoic acid, 2-(2-fluoro-4-biphenyl)propionic acid, 2-(4-isobutylphenyl) propionic acid and 2-(3-benzoylphenyl)-propionic acid were synthesized. These compounds were structurally characterized by infrared and multinuclear NMR (1H, 13C, 119Sn) spectroscopies and mass spectrometry. The isotopic effect of tin was studied by comparison of experimental data with the simulated isotopic pattern using the Chemtool software package. These compounds were also screened against different animal and plant pathogens to study their biological activity. LD50 data show that the reported compounds have significant toxicity.