Staphylococcus aureus biofilm activates the nucleotide‐binding oligomerization domain containing 2 (Nod2) pathway and proinflammatory factors on a human sinonasal explant model

Abstract

S. aureus biofilms exerted a proinflammatory response in the mucosa and activation of the Nod2 pathway, indicating this receptor to be involved in the innate immune response to S. aureus biofilms. Further studies are required to elucidate the role of this pathway in CRS.