The bradykinin <scp>B</scp>1 receptor antagonist <scp>BI</scp>113823 reverses inflammatory hyperalgesia by desensitization of peripheral and spinal neurons

Abstract

The selective bradykinin B1 receptor antagonist BI113823 reduces CFA-induced mechanical hyperalgesia which is mediated via antagonism of peripheral as well as spinal bradykinin B1 receptors. The selective modulation of CFA-sensitized spinal NS neurons by BI113823 could be a promising property for the treatment of inflammatory pain.