Involvement of neuronal <scp>TGF</scp>‐<scp>β</scp> activated kinase 1 in the development of tolerance to morphine‐induced antinociception in rat spinal cord

Abstract

TAK1 played a pivotal role in the development of morphine-induced antinociceptive tolerance. Modulation of TAK1 activation by the selective inhibitor OZ in the lumbar spinal cord may prove to be an attractive adjuvant therapy to attenuate such tolerance.