Synthesis of Virus-capsid Antigen (VCA) Enhanced by Ultraviolet Irradiation of a Lymphoblastoid Cell Line carrying Epstein--Barr Virus

Abstract

SUMMARY U.v. irradiation of SH-RP cells, a lymphoblastoid cell line carrying Epstein–Barr virus, which was derived from a patient with acute myeloid leukaemia, retarded cell growth but significantly enhanced the percentage of cells containing virus-capsid antigen (VCA) as demonstrated by indirect immunofluorescence. The effects of u.v. irradiation on SH-RP cultures were reversible under normal conditions of medium replenishment every four days. Starving the cultures did not modify these effects.