Long-term effects for acute phase myocardial infarct VEGF₁₆₅gene transfer cardiac extracellular matrix remodeling

Abstract

The data obtained strongly support the idea that changes in the ECM and its components are important determinants of cardiac remodeling after myocardium infarct and may be essential for inflammatory response and attempt to stabilize the damage and provide a compensatory mechanisms to maintain cardiac output since the ECM components analyzed are involved with angiogenesis, cell proliferation and differentiation.