Concepedia

Emergence in Italy of a <i>Neisseria meningitidis</i> Clone with Decreased Susceptibility to Penicillin

Paola Stefanelli, Cecilia Fazio, Arianna Neri, Tonino Sofia, Paola Mastrantonio

Antimicrobial Agents and Chemotherapy · 2004 · 18 citations · 10 references

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Abstract

A rise in invasive diseases due to Neisseria meningitidis C:2b:P1.5 with decreased penicillin susceptibility occurred in Italy during the last 2 years. Real-time PCR identified the Peni phenotype, and the penA sequence revealed the mosaicism of the gene. Molecular analyses assigned the isolates to a single emergent clone of the hypervirulent A4 cluster.

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