DNA and RNA in Anhydrous Media: Duplex, Triplex, and G‐Quadruplex Secondary Structures in a Deep Eutectic Solvent

Abstract

Hold the water! Deep-eutectic solvents (DESs) are nonvolatile media suitable for a wide range of chemical reactions. The discovery that nucleic acids can form duplex, triplex, and G-quadruplex structures (which in some cases differ from those adopted in aqueous media) in a water-free DES (see picture) opens the enticing possibility that catalytic nucleic acids and enzyme–nucleic acid complexes could also be used in these solvents. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.