Pathologic Complete Response Rates in Young Women With <i>BRCA1</i>-Positive Breast Cancers After Neoadjuvant Chemotherapy

Abstract

A low rate of pCR was observed in women with breast cancer and a BRCA1 mutation who were treated with AT or CMF. A high rate of pCR was seen after treatment with cisplatin. An intermediate rate of PCR was associated with AC or FAC. The relative benefits of AC and platinum therapy need to be confirmed through follow-up of this and other cohorts.