Treatment of arthritis by macrophage depletion and immunomodulation: Testing an apoptosis‐mediated therapy in a humanized death receptor mouse model

Abstract

The anti-human DR5 antibody TRA-8 was efficacious in reducing the severity of arthritis via targeted depletion of macrophages and immunomodulation. Our data provide preclinical evidence that TRA-8 is a potential novel biologic agent for rheumatoid arthritis therapy.