Role of systemic and local administration of selective inhibitors of cyclo‐oxygenase 1 and 2 in an experimental model of periodontal disease in rats

Abstract

Our results provide evidence for participation of COX-1 and COX-2 in early stages of periodontal disease in rats. Furthermore, local administration of COX inhibitors reduced the signs of periodontal disease to the same extent as systemic treatment. Therapeutic approaches incorporating locally delivered anti-inflammatory drugs could be of benefit for patients suffering from periodontal disease.