Ibuprofen as a pre-emptive analgesic is as effective as rofecoxib for mandibular third molar surgery

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

John R. Vane · Nature New Biology · 1971 · 8.6K citations

Life Sciences, Medicinal Chemistry, Pharmacology +10

Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs

M. J. S. Langman, J Weil, Paul Wainwright et al. · The Lancet · 1994 · 877 citations

Medicine, Pharmacology, Pharmacotherapy +10

Studies with different types of visual analog scales for measurement of pain

Kampon Sriwatanakul, William Kelvie, Louis Lasagna et al. · Clinical Pharmacology & Therapeutics · 1983 · 475 citations

Medicine, Anesthesiology, Pain Medicine +15

Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model

Elliot Ehrich, A. Dallob, I Delepeleire et al. · Clinical Pharmacology & Therapeutics · 1999 · 326 citations

Medicine, Pharmacology, Pharmacotherapy +16

COX-1, COX-2, and COX-3 and the future treatment of chronic inflammatory disease

D. A. Willoughby, Adrian Moore, Paul Colville‐Nash · The Lancet · 2000 · 303 citations

Veterinary Medicine, Pharmacotherapy, Inflammation +10