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ASYMPTOMATIC GASTRIC RETENTION IN DIABETICS (GASTROPARESIS DIABETICORUM)

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1958

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Article1 April 1958ASYMPTOMATIC GASTRIC RETENTION IN DIABETICS (GASTROPARESIS DIABETICORUM)PAUL KASSANDER, M.D.PAUL KASSANDER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-4-797 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe incidental discovery of unsuspected and asymptomatic gastric retention in moderately severe diabetics led to a study of this condition. References to gastric retention in diabetes are very scanty in current literature.Motility disturbances of the gastrointestinal tract in general have always been a part of the symptomatology of diabetes mellitus. Constipation and diarrhea, with or without anorexia and nausea, have been well known to accompany diabetes. "Diabetic diarrhea," nocturnal as well as diurnal, remains a severe complication. Marble1 was one of the first to suggest the possibility of a neurogenic origin for this syndrome.Gastric retention, in clinical medicine...Bibliography1. MarbleJoslinRootWhiteMarble AEPHFPA: The treatment of diabetes mellitus, 9th Ed., 1952, Lea & Febiger, Philadelphia, pp. 480-481 and 485. Google Scholar2. Wood MN: Chronic peptic ulcer in ninety-four diabetics, Am. J. Digest. Dis. 14: 1-11, 1947. CrossrefMedlineGoogle Scholar3. Quigley JP: Gastric motility and evacuation, in Peptic ulcer, edited by David T. Sandweiss, 1951, W. B. Saunders Co., Philadelphia, p. 75-81. Google Scholar4. Rundles RW: Diabetic neuropathy, Medicine 24: 111-160, 1945. CrossrefGoogle Scholar5. HodgesRundlesHanelin FJRWJ: Roentgenologic study of small intestine. II. Dysfunction associated with neurologic diseases, Radiology 49: 659-673, 1947. CrossrefMedlineGoogle Scholar6. GoldenLepore RMJ: Syndrome due to deficiency of vitamin B complex, J. A. M. A. 117: 918-923, 1941. CrossrefGoogle Scholar7. Martin MM: Diabetic neuropathy, a clinical study of 150 cases, Brain 76: 594-624, 1953. CrossrefMedlineGoogle Scholar8. Golden R: Diagnostic roentgenology, Vol. 1, 1948, Thomas Nelson, New York, p. 340G. Google Scholar9. MooreChapmanSchultzJones FDWPMDCM: Transdiaphragmatic resection of vagus nerves for peptic ulcer, New England J. Med. 234: 241-251, 1946. CrossrefMedlineGoogle Scholar10. JoslinJoslinRootWhiteMarble EPEPHFPA: Diabetes mellitus, 9th Ed., 1952, Lea & Febiger, Philadelphia, p. 97. Google Scholar11. Katschvon BergmannStaehelin GGR: Handbook of internal medicine, 2nd Ed., 1926, Julius Springer, Berlin, pp. 522-527. Google Scholar12. Schlesinger E: Chronische Gastroparese als Ursache schwerer motorischer Insufficienz bei freiem Pylorus, Mitt. a. d. Grenzgeb. d. med. u. Chir. 32: 30, 1920. Google Scholar13. Boas T: Disease of the stomach, 9th Ed., 1925, Georg Thieme, Leipzig, p. 200. Google Scholar14. GoodmanGilman LA: The pharmacological basis of therapeutics, 1947, The Macmillan Co., New York, pp. 760-761, 860-861. Google Scholar15. KeilinMann DT: Carbonic anhydrase, Biochem. J. 34: 1163-1176, 1940. CrossrefMedlineGoogle Scholar16. Vallee BL: Metabolic role of zinc, J. A. M. A. 162: 1053-1057, 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Manchester, New Hampshire*Presented at the Thirty-eighth Annual Session of The American College of Physicians, Boston, Massachusetts, April 11, 1957.From the Medical Service of the Veterans Administration Hospital, Manchester, New Hampshire.Requests for reprints should be addressed to Paul Kassander, M.D., Chief, Medical Service, Veterans Administration Hospital, Smyth Road, Manchester, New Hampshire. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUpper Gastrointestinal Manifestations of DiabetesGastroparesis with Cannabis Use: A Retrospective Study from the Nationwide Inpatient SampleDigesting the pathogenesis of diabetic gastroparesisGastroparesisA Study on Assessment and Management of Diabetic GastropathyNiche-specific functional heterogeneity of intestinal resident macrophagesEndoscopic Management of GastroparesisGastric Emptying Abnormalities in Diabetes MellitusRelationship of motor mechanisms to gastroparesis symptoms: toward individualized treatmentDay-to-Day Variations in Fasting Plasma Glucose Do Not Influence Gastric Emptying in Subjects With Type 1 DiabetesClinical presentations of gastroparesisNatural history of patients with gastroparesisCellular pathogenesis of gastroparesisDiabetic gastroparesisA vision of the future for gastroparesisStudy on the Mechanisms of Banxia Xiexin Decoction in Treating Diabetic Gastroparesis Based on Network PharmacologyGastrointestinal autonomic neuropathy in diabetesThe Role of Diabetes Mellitus in Diseases of the Gallbladder and Biliary TractGastric Biopsies in GastroparesisGastroparesis: New insights into an old diseaseGastroparesis: New insights into an old diseaseGastroparesis versus dyspepsia by intragastric meal distribution: new diagnostics and definitions aheadDiabetes and the Gastrointestinal TractRapid gastric emptying in diabetes mellitus: Pathophysiology and clinical importanceDiabetic GastroparesisClinical Manifestation and Natural History of GastroparesisCharacterization of Upper Gastrointestinal Symptoms, Gastric Motor Functions, and Associations in Patients with Diabetes at a Referral CenterImpaired neural pathway in gastric muscles of patients with diabetesBidirectional Relationship between Gastric Emptying and Plasma Glucose Control in Normoglycemic Individuals and Diabetic PatientsGastric Emptying and the Personalized Management of Type 1 DiabetesDiabetic Gastroparesis: Principles and Current Trends in ManagementThe Investigation and Treatment of Diabetic GastroparesisCorrelation of dyspeptic symptoms and endoscopic findings in diabetic patientGlass half empty? Lessons learned about gastroparesisNutrition Management of Patients with Diabetic GastroparesisDiabetes and the StomachAnalysis of the Relationship between Helicobacter pylori Infection and Diabetic GastroparesisRelationship of gastric emptying or accommodation with satiation, satiety, and postprandial symptoms in healthRole of wireless motility capsule in the assessment and management of gastrointestinal dysmotility in patients with diabetes mellitusGastroparesis post-laparoscopic cholecystectomy in diabetic patientsSplit-dose bowel preparation with polyethylene glycol for colonoscopy performed under propofol sedation. Is there an optimal timing?Diabetic Gastroparesis Presenting with a Cyclic Vomiting PatternGastrointestinal Manifestations of DiabetesNovel insights into the effects of diabetes on gastric motilityCharacterization of smooth muscle, enteric nerve, interstitial cells of Cajal, and fibroblast-like cells in the gastric musculature of patients with diabetes mellitusDelayed Gastric Emptying Is Associated With Early and Long-term Hyperglycemia in Type 1 Diabetes MellitusAutonomic neuropathyRelationship Between Glycemic Control and Gastric Emptying in Poorly Controlled Type 2 DiabetesGastric Electrical Stimulation with the Enterra System: A Systematic ReviewMeasurement of gastric emptying in diabetescAMP-dependent insulin modulation of synaptic inhibition in neurons of the dorsal motor nucleus of the vagus is altered in diabetic miceDiabetic autonomic neuropathyDelayed gastric emptying after pancreaticoduodenectomy in diabetes mellitusThe Relation Between Symptom Improvement and Gastric Emptying in the Treatment of Diabetic and Idiopathic GastroparesisDiagnostic Assessment of Diabetic GastroparesisPrevalence of symptoms suggestive of gastroparesis in a cohort of patients with diabetes mellitusNew perspectives in the diagnosis and management of enteric neuropathiesMeasurement of gastric emptying by radiopaque markers in patients with diabetes: correlation with scintigraphy and upper gastrointestinal symptomsDiabetic gastroparesis: recent insights into pathophysiology and implications for managementGastric Electrical Stimulation: Twentieth Century Development to Twenty-First Century Implementation and Personalization of ProgrammingChinese Herbal Medicine Banxiaxiexin Decoction Treating Diabetic Gastroparesis: A Systematic Review of Randomized Controlled TrialsDiabetic gastroparesis: pathophysiology, evaluation and managementNeuropathy in the gut. Gut motility disorders in patients with diabetes mellitusCorrelation between symptoms of diabetic gastroparesis and results of gastric scintigraphyNatural History of Patients with GastroparesisGastroparesis: Concepts, Controversies, and ChallengesDoes Grading the Severity of Gastroparesis Based on Scintigraphic Gastric Emptying Predict the Treatment Outcome of Patients with Gastroparesis?Gastroparesis: Approach, Diagnostic Evaluation, and ManagementDiabetic gastroparesis-Backwards and forwardsGastric Electrical Stimulation With Enterra Therapy Improves Symptoms From Diabetic Gastroparesis in a Prospective StudyAdvantages of Azithromycin Over Erythromycin in Improving the Gastric Emptying Half-Time in Adult Patients With GastroparesisGastrointestinal Manifestations of DiabetesDelayed Radionucleotide Gastric Emptying Studies Predict Morbidity in Diabetics With Symptoms of GastroparesisThe Incidence, Prevalence, and Outcomes of Patients With Gastroparesis in Olmsted County, Minnesota, From 1996 to 2006The Stomach in Diabetes: From Villain to AllyRelationship between clinical features and gastric emptying disturbances in diabetes mellitusUltrasonographic comparison of gastric motility between diabetic gastroparesis patients with and without metabolic syndromePharmacological and non-pharmacological interventions for symptomatic gastroparesisGastroparesis-Related Hospitalizations in the United States: Trends, Characteristics, and Outcomes, 1995–2004Azithromycin in an Older Woman With Diabetic GastroparesisGastrointestinal and Autonomic Complications of Diabetes MellitusGastroparesis in type 2 diabetes mellitus: Prevalence, etiology, diagnosis, and treatmentDiabetic GastroparesisRelationships between insulin resistance, blood glucose levels and gastric motility: an electrogastrography and external ultrasonography studyElectrogastrography in children and adolescents with type 1 diabetes: Weak correlation with metabolic control parameters1Results of this study were presented during the Second WCPGHAN, Paris, 2004, and published as an abstract in J Pediatr Gastroenterol Nutr 2004:39 Suppl 1:S41.'Gastric' hypoglycaemia - an important concept in diabetes managementDiabetische GastropareseUltrasonographic assessment of gastric motility in diabetic gastroparesis before and after attaining glycemic controlManagement of Gut DysmotilityChapter 2 Unmyelinated nerves, challenges, and opportunities: skin biopsy and beyondNutrition therapy for diabetic gastroparesisDiagnosis and treatment of chronic gastroparesis and chronic intestinal pseudo-obstructionMeasurement of gastric contraction activity in dogs by means of AC biosusceptometryCurrent Concepts in Diabetic GastroparesisGlucagon-Like Peptide 1 and Gastric Inhibitory PolypeptideAcute effect of clonidine on gastric emptying in patients with diabetic gastropathy and controlsGallbladder and gastric emptying: relationship to cholecystokininemia in diabeticsContinuous Glucose Monitoring System: A New Approach to the Diagnosis of Diabetic GastroparesisInsulin restores neuronal nitric oxide synthase expression and function that is lost in diabetic gastropathyPotato-Lactulose Breath Hydrogen Testing as a Function of Gastric Motility in Diabetes MellitusThe Diagnosis and Work-up of the Patient With GastroparesisMechanism of Delayed Gastric Emptying in Naturally Occurring CCK-A Receptor Gene Knockout (OLETF) Rats.Gastrointestinal Motor Dysfunction, Symptoms, and Neuropathy in Noninsulin-Dependent (Type 2) Diabetes MellitusCisapride Versus Placebo for 8 Weeks on Glycemic Control and Gastric Emptying in Insulin-Dependent Diabetes: A Double Blind Cross-Over Trial1Gastrointestinale Komplikationen des Diabetes mellitusNovel surgical treatment and gastric pathology in diabetic gastroparesisGastric Emptying in Diabetes Mellitus: Relationship to Blood-Glucose ControlA Double-Blind Multicenter Comparison of Domperidone and Metoclopramide in The Treatment of Diabetic Patients With Symptoms of Gastroparesis Fig. 1Diabetic Neuropathies: Features and MechanismsPrevalence of Gastrointestinal Symptoms in Young and Middle-Aged Diabetic PatientsHyperglycaemia Attenuates Erythromycin-Induced Acceleration of Solid-Phase Gastric Emptying in Idiopathic and Diabetic GastroparesisDIABETES AND THE GASTROINTESTINAL TRACTGASTROINTESTINAL COMPLICATIONS OF RENAL FAILURELarge Intestinal Endocrine Cells in Non-Obese Diabetic MiceDiabetic Autonomic NeuropathyGastrointestinal DisordersGastric Meal Accommodation Studied by Ultrasound in Diabetes: Relation to Vagal ToneImpaired insulin but normal pentagastrin effect on gastric acid secretion in diabetic rats: a role for nitric oxideCalmodulin content and in vitro contractility of duodenum from streptozotocin-induced diabetic rats: effects of insulin therapy and calmodulin antagonismGASTROINTESTINAL PROBLEMS IN DIABETESWide gastric antrum and low vagal tone in patients with diabetes mellitus type 1 compared to patients with functional dyspepsia and healthy individualsDiabetic gastroparesisDiabetic autonomic neuropathyMechanism of accelerated gastric emptying of liquids and hyperglycemia in patients with type II diabetes mellitusTHE PROPORTIONAL CUMULATIVE AREA UNDER THE CURVE OF PARACETAMOL USED AS AN INDEX OF GASTRIC EMPTYING IN DIABETIC PATIENTS WITH SYMPTOMS OF GASTROPARESISEffect of diabetes on relaxations to non-adrenergic, non-cholinergic nerve stimulation in longitudinal muscle of the rat gastric fundusGastrointestinal motility disorders in patients with diabetes mellitusMediation of hyperglycemia-evoked gastric slow-wave dysrhythmias by endogenous prostaglandinsGastric emptying response to variable oral erythromycin dosing in diabetic gastroparesisThe effects of glyburide and insulin on the decreased β-adrenergic responsiveness of the gastrointestinal tract in rats with non-insulin-dependent diabetesVanadate treatment reverses gastrointestinal complications in the streptozotocin-diabetic ratsDiabetic gastroparesis in perspectiveManagement of the Trauma Victim with Pre-Existing Endocrine DiseaseDisordered gastric motor function in diabetes mellitusDiabetic gastroparesisPudendal neuropathy in diabetic patients with faecal incontinenceRelationships between dyspeptic symptoms and gastrointestinal motility in patients with Type 1 (insulin-dependent) diabetes mellitusDiabetic Gastropathy in Patients with Autonomic NeuropathyPrevention of neuropathy in the pyloric sphincter of streptozotocin-diabetic rats by gangliosidesDiabetes MellitusBasal and histamine-induced gastric acid secretion in alloxan diabetic ratsGastrointestinal Symptoms in Middle-Aged Diabetic PatientsIncreased volume of gastric contents in diabetic patients undergoing renal transplantation: lack of effect with cisaprideEvidence of Impaired Afferent Vagal Function in Patients with Diabetes Gastroparesisβ-Adrenergic Responsiveness of the Gastrointestinal Tract in Diabetic RatsPrognostic implication of gastroparesis in patients with diabetes mellitusSegmental gut transit in diabetes mellitus: effect of cisaprideEffect of lithium on gastro-intestinal complications in alloxan-diabetic ratsDiabetic Neuropathic Cachexia Associated with MalabsorptionPathophysiologie von Motilitätsstörungen im oberen GastrointestinaltraktDisordered Gastric Motor Function in Diabetes Mellitus: Recent Insights into Prevalence, Pathophysiology, Clinical Relevance, and TreatmentHyperglycaemia slows gastric emptying in Type 1 (insulin-dependent) diabetes mellitusVagus Nerve Morphology in Diabetic GastropathyComparison between gastric emptying of digestible and indigestible solids in diabetic patientsVariations in Gastric Tone Associated with Duodenal Motor Events After Activation of Central Emetic Mechanisms in the DogBehandlung von Motilitätsstörungen des Magens mit ProkinetikaEffect on the postprandial glycaemic level of the addition of water to a meal ingested by healthy subjects and Type 2 (non-insulin-dependent) diabetic patientsGastric and oesophageal emptying in patients with Type 2 (non-insulin-dependent) diabetes mellitusAssociation between Disturbances in Gastrointestinal Transit and Functional Bowel DiseaseFunctional Causes of Disturbed Gastric FunctionRoux-Y gastrectomy for chronic gastric atonyDiabetic GastroparesisAspiration pneumonitis following electroconvulsive therapy in patients with gastroparesisEvaluation of gastrin secretion in diabetic subjects with normal or abnormal cardiovascular autonomic function testsUpper gastrointestinal involvement in diabetes mellitus: Study of esophagogastric functionAsymptomatic gastric retention and diabetic neuropathyClinical aspects of diabetic neuropathiesThere are no morphologic abnormalities of the gastric wall or abdominal vagus in patients with diabetic gastroparesisDecreased gastro-intestinal responses to salbutamol and serotonin in streptozotocin-induced diabetes: Improving effect of insulin in vivo and in vitroEffect of cisapride on gastric and esophageal emptying in insulin-dependent diabetes mellitusMeasurement by Epigastric Impedance of Gastric Emptying in Diabetic Autonomic NeuropathyGastric emptying disordersErkrankungen des GastrointestinaltraktsEtiologyEffect of cisapride on gastric emptying of indigestible solids in patients with gastroparesis diabeticorumGastroparesis after radiationAutonomic neuropathy: its diagnosis and prognosisPyloric dysfunction in diabetics with recurrent nausea and vomitingA Form of Necrobiosis and Atrophy of Smooth Muscle in Diabetic Gastric Autonomic NeuropathyGastric and oesophageal emptying in insulin-dependent diabetes mellitusDiabetic autonomic neuropathyTreatment of Diabetic Gastroparesis with Oral DomperidoneBronchoscopy in Patients with GastroparesisMeasurement of gastric emptying in dyspeptic patients: effect of a new gastrokinetic agent (cisapride).Effect of metoclopramide on gastric liquid emptying in patients with diabetic gastroparesisAbnormal intestinal motility in diabetics with the gastroparesis syndromeGastric emptying of solid radiopaque markers: Studies in healthy subjects and diabetic patientsUnexplained Vomiting: A Diagnostic ChallengeJUAN-R. MALAGELADA, M.D., MICHAEL CAMILLERI, M.D.Diabetic gastroparesis from autonomic neuropathy: surgical considerations and changes in vagus nerve morphology.The Physiology and Pathophysiology of Gastric Emptying in HumansGastric Emptying in Patients With Diabetes MellitusErkrankungen des GastrointestinaltraktsGastrointestinal Complications of Diabetes MellitusDisorders of Gastrointestinal Motility Associated with Diabetes MellitusMARK FELDMAN, M.D., LAWRENCE R. SCHILLER, M.D.Metoclopramide: Pharmacology and Clinical ApplicationRIYAD ALBIBI, M.D., RICHARD W. McCALLUM, M.D.Stressful Life Events, Acid Hypersecretion, and Ulcer DiseaseMetoclopramide to Treat Gastroparesis due to Diabetes Mellitus A Double-Blind, Controlled TrialWILLIAM J. SNAPE Jr., M.D., WILLIAM M. BATTLE, M.D., STANLEY S. SCHWARTZ, M.D., SETH N. BRAUNSTEIN, M.D.Ph.D., HAROLD A. GOLDSTEIN, M.D., ABASS ALAVI, M.D.Motor Disorders of the StomachBiologic gastric emptying time using Tc-99m TETA polystyrene resin in various clinical conditionsColonic dysfunction in diabetes mellitusThe role of autonomic neuropathy in diabetic foot ulcerationPathogenesis of diabetic gastroparesis: A pharmacologic studyGastric motor abnormalities in diabetic and postvagotomy gastroparesis: Effect of metoclopramide and bethanecholDiabetic autonomic neuropathyAbnormal Gastric Function in Longstanding, Insulin-Dependent Diabetic PatientsDiabetes and the gut.CARDIORESPIRATORY ARREST IN DIABETIC NEUROPATHYGastric emptying in diabetic autonomic neuropathy.Erkrankungen des Magen-Darm-Traktes bei Diabetes mellitusDie diabetische NeuropathieDiabetic neuropathy: Clinical aspectsOesophageal motor changes in diabetes mellitus.ACUTE DIABETIC ABDOMEN IN CHILDHOODManagement of Severe Diabetic KetoacidosisMetoclopramide for Gastroparesis DiabeticorumRapid Gastric Emptying of Fatty Meals in Pancreatic InsufficiencyI sintomi digestivi del diabete mellitoThe PancreasDiabetes and the bowelCurrent status of diabetic neuropathyNeuropatía Diabética VisceralGASTRIC ACID SECRETORY RESPONSE TO PENTAGASTRIN INFUSION IN DIABETES MELLITUSEndocrine Problems in OtolaryngologyPENTAGASTRIN‐ AND INSULIN‐INDUCED SECRETION IN DIABETES MELLITUSVAGAL FUNCTION IN PATIENTS WITH DIABETIC NEUROPATHYA Comparative Study of Esophageal Motility in Diabetics with NeuropathyGastrointestinal Manifestations of Diabetes MellitusSull'incidenza dell'ernia dello hiatus nei soggetti diabetici: Considerazioni patogeneticheDiabetic Diarrhea and Steatorrhea Microbiologic and Clinical ObservationsFRANZ GOLDSTEIN, M.D., F.A.C.P., C. W. WIRTS, M.D., F.A.C.P., O. DHODANAND KOWLESSAR, M.D.Gastrointestinal Syndromes Due to Diabetes MellitusChanges in the sympathetic nervous system in diabetes mellitusGastric neuropathy in diabetes mellitus: Clinical and radiologic observationsDiabetes and SteatorrhoeaGastrointestinal Manifestations of DiabetesDiabetes and the Nervous SystemGastric emptying and secretion in patients with diabetes mellitusDiabetic gastropathyReferencesPhysiologic studies of autonomic-nervous-system dysfunction accompanying diabetes mellitusOn the Pathogenesis of Diabetic SteatorrheaS. M. SUMI, M.D., J. M. FINLAY, M.D., F.R.C.P. (C), F.A.C.P.Gastric Emptying in Diabetes MellitusGastric Retention and Hypoglycaemia in Diabetes 1 April 1958Volume 48, Issue 4Page: 797-812KeywordsDiarrheaDuodenal ulcersGastrointestinal tractGastroparesisInsulinInsulin signalingInsulin-like growth factorsMedical servicesNauseaZinc Issue Published: 1 April 1958 PDF downloadLoading ...

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