Angiotensin 1–7 Ameliorates Diabetic Cardiomyopathy and Diastolic Dysfunction in <i>db/db</i> Mice by Reducing Lipotoxicity and Inflammation

Abstract

We identified a novel beneficial effect of Ang 1-7 on diabetic cardiomyopathy that involved a reduction in cardiac hypertrophy and lipotoxicity, adipose inflammation, and an upregulation of adipose triglyceride lipase. Ang 1-7 completely rescued the diastolic dysfunction in the db/db model. Ang 1-7 represents a promising therapy for diabetic cardiomyopathy associated with type 2 diabetes mellitus.