Facile Synthesis of Copper(II)Immobilized on Magnetic Mesoporous Silica Microspheres for Selective Enrichment of Peptides for Mass Spectrometry Analysis

Abstract

Captivating pores: Copper ions were immobilized on mesoporous silica shells with perpendicularly aligned pore channels, formed on Fe3O4 cores through a surfactant-templated sol–gel process. The highly accessible mesopores, large in-pore surface, and numerous Cu2+ ions on the microspheres allowed selective capture of hydrophobic and hydrophilic peptides from complex biosamples followed by magnetic separation and MS analysis (see picture). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.