Steady-state pharmacokinetics of delavirdine in HIV-positive patients: Effect on erythromycin breath test *

Abstract

Delavirdine is a potent and reversible inhibitor of hepatic CYP3A; it is also a substrate for this CYP450 isoform. It is likely that delavirdine will exhibit drug-drug interactions when coadministered with other CYP3A substrates.