A pH‐Responsive Drug‐Delivery Platform Based on Glycol Chitosan–Coated Liposomes

Abstract

pH-responsive liposomes are prepared by conjugating glycol chitosan (GC) to the outer lipid membrane. This functionalization allows the liposomes to transition from a negative charge at physiologic pH to a positive charge in the acidic extracellular tumor microenvironment. Upon obtaining a positive charge, the GC-liposomes loaded with doxorubicin exhibited enhanced cellular uptake and improved anticancer efficacy. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.