Organocatalytic Asymmetric Inverse‐Electron‐Demand Diels–Alder Reaction of Electron‐Deficient Dienes and Crotonaldehyde

Abstract

Another pathway for enals: The excellent β,γ-regioselectivity shown in the title reaction under dienamine catalysis efficiently gave highly diastereo- and enantioenriched cyclohexene derivatives with substantial substitution diversity (see scheme; EWG=electron-withdrawing group, TMS=trimethylsilyl).